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A triacylglycerol; been used to characterize the functionality of R. oryzae lipase for regiodistribution analysis of fats containing medium- and short-chain fatty acids
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DMG-PEG2000-Biotin is a synthetic amphiphilic molecule composed of dimyristoyl glycerol (DMG) polyethylene glycol (PEG2000) and biotin functionalities It is commonly employed in biomedical research for surface modification of lipid-based delivery platforms such as lipid nanoparticles (LNPs) and liposomes The PEG moiety enhances colloidal stability prolongs circulation time and reduces rapid clearance in vivo The biotin termination facilitates conjugation to streptavidin-tagged biomolecules exploiting the highly specific biotin-streptavidin interaction Thus DMG-PEG2000-Biotin is valuable for drug-delivery optimization targeted therapeutic approaches and in vitro diagnostic assay development
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An ionizable cationic lipid (apparent pKa = 6.44); has been used in the generation of lipid nanoparticles (LNPs) encapsulating siRNA, mRNA, or plasmid DNA for use in vitro and in vivo; LNPs containing DLin-MC3-DMA accumulate in the muscle and non-draining lymph nodes after intramuscular administration and in the spleen after intravenous administration in mice; LNPs containing DLin-MC3-DMA and encapsulating F7 siRNA reduce hepatic and plasma Factor VII levels in mice without inducing liver toxicity
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